President Obama spoke at American University on August 5. In defense of the Iran nuclear agreement he said many things, worth thinking about. Among them a recognition that U.S. and Israeli national interests (at least as seen by PM Netanyahu) are not congruent:

OBAMA: "I have also listened to the Israeli security establishment, which warned of the danger posed by a nuclear armed Iran for decades. In fact, they helped develop many of the ideas that ultimately led to this deal. So to friends of Israel and the Israeli people, I say this. A nuclear armed Iran is far more dangerous to Israel, to America, and to the world than an Iran that benefits from sanctions relief.

"I recognize that prime minister Netanyahu disagrees, disagrees strongly. I do not doubt his sincerity, but I believe he is wrong. I believe the facts support this deal. I believe they are in America's interests and Israel's interests, and as president of the United States it would be an abrogation of my constitutional duty to act against my best judgment simply because it causes  temporary friction with a dear friend and ally.

"I do not believe that would be the right thing to do for the United States, I do not believe it would be the right thing to do for Israel."

The text of the talk from the Washington Post.   

Paul Pillar analyses Obama's idea of "mindsets."